~ editorial
~ severe ME
~ ME & children
~ grassroot
~ biopsychosocial
~ news from:
19 countries
5 charities
4 authorities
~ petitions
~ events
~ science/research
~ poem
From the editors
List of contributors
The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Jason, McGarrigle, Vermeulen
Abstract
Individuals with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS) often experience autonomic symptoms.
Participants & methods
In the present study, we evaluated 193 adults seeking treatment for ME/CFS, who were recruited from an outpatient clinic.
The participants completed a head-up tilt table test to assess two common types of orthostatic intolerance, namely, postural orthostatic tachycardia syndrome (POTS) and orthostatic hypotension (OH).
Lees verder “The Head-Up Tilt Table Test as a Measure of Autonomic Functioning among Patients with Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”
Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies
Annesley, Missailidis, Heng, Josev, Armstrong
Highlights
Approximately half of patients with long COVID (LC) fulfil the diagnostic criteria for myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS). The two conditions share clinical similarities and proposed disease pathologies, but it is still unclear whether they also share common molecular abnormalities.
Most consistently altered pathologies in ME/CFS and LC include an increased reliance on alternatives to carbohydrates as substrates for energy production and altered gut microbiota, with a reduction in butyrate-synthesising bacteria.
Lees verder “Unravelling shared mechanisms: insights from recent ME/CFS research to illuminate long COVID pathologies”
Changing patterns of multimorbidity among patients with ambiguous diagnoses: The case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome
Bragée, Carlsson, Sjögren, Bertilson
Abstract
Introduction
Increased attention has been given to multimorbidity. This phenomenon often has been explored through associations between diseases based on the frequency of combinations of diagnoses.
A more patient-focused strategy, together with a trajectory of the multimorbidity situation, has recently attracted increased interest.
Lees verder “Changing patterns of multimorbidity among patients with ambiguous diagnoses: The case of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome”
Remission of severe forms of long COVID following monoclonal antibody (MCA) infusions: A report of signal index cases and call for targeted research
K. Scheppke, Pepe, Jui, Crowe PhD h, E. Scheppke, Klimas, Marty
Abstract
Objective
Long COVID has afflicted tens of millions globally leaving many previously-healthy persons severely and indefinitely debilitated. The objective here was to report cases of complete, rapid remission of severe forms of long COVID following certain monoclonal antibody (MCA) infusions and review the corresponding pathophysiological implications.
Lees verder “Remission of severe forms of long COVID following monoclonal antibody (MCA) infusions: A report of signal index cases and call for targeted research”
Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated Virus-Host Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
Hsieh, Savva, Telatin, Tiwari, Tariq, Newberry, Seton, Booth, Bansal, Wileman, Adriaenssens, Carding
Abstract
Understanding how the human virome, and which of its constituents, contributes to health or disease states is reliant on obtaining comprehensive virome profiles.
By combining DNA viromes from isolated virus-like particles (VLPs) and whole metagenomes from the same faecal sample of a small cohort of healthy individuals and patients with severe myalgic encephalomyelitis/chronic fatigue syndrome (ME/CFS), we have obtained a more inclusive profile of the human intestinal DNA virome.
Lees verder “Investigating the Human Intestinal DNA Virome and Predicting Disease-Associated Virus-Host Interactions in Severe Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)”
Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression
Berkis, Svirskis, Krumina, Gravelsina, Vilmane, Araja, Nora-Krukle, Murovska
Abstract
Background
Recently, the research of our group revealed that antibodies to beta2-adrenergic (anti-β2AdR) and muscarinic acetylcholine (anti-M4) receptors demonstrate sensitivity to the progression of ME/CFS.
The purpose of this study is to investigate the joint potential of inflammatome-characterized by interferon (IFN)-γ, tumor necrosis factor (TNF)-α, interleukin (IL)-2, IL-21, Il-23, IL-6, IL-17A, Activin-B, immunome (IgG1, IgG2, IgG3, IgG4, IgM, and IgA), and receptor-based biomarkers (anti-M3, anti-M4, and anti-β2AdR)-for evaluating ME/CFS progression, and to identify an optimal selection for future validation in prospective clinical studies.
Lees verder “Exploring the joint potential of inflammation, immunity, and receptor-based biomarkers for evaluating ME/CFS progression”
Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation
Tien Vu, Ahmed, Zhu, Hanson, Grenier, Grimson
Highlights
• The ME/CFS immune system is profiled by scRNA-seq at baseline and after provocation
• Monocyte dysregulation is prominent and dysregulation correlates with disease severity
• Platelets are also dysregulated, but this dysregulation resolves after provocation
Lees verder “Single-cell transcriptomics of the immune system in ME/CFS at baseline and following symptom provocation”
The ME Global Chronicle 